diff --git a/polygerrit-ui/app/elements/core/gr-error-manager/gr-error-manager_test.js b/polygerrit-ui/app/elements/core/gr-error-manager/gr-error-manager_test.js
index 092daa2..3f6148b 100644
--- a/polygerrit-ui/app/elements/core/gr-error-manager/gr-error-manager_test.js
+++ b/polygerrit-ui/app/elements/core/gr-error-manager/gr-error-manager_test.js
@@ -21,6 +21,7 @@
 import {__testOnly_ErrorType} from './gr-error-manager.js';
 import {stubRestApi} from '../../../test/test-utils.js';
 import {appContext} from '../../../services/app-context.js';
+import {createPreferences} from '../../../test/test-data-generators.js';
 
 const basicFixture = fixtureFromElement('gr-error-manager');
 
@@ -40,6 +41,8 @@
           .returns(Promise.resolve({ok: true, status: 204}));
       getLoggedInStub = stubRestApi('getLoggedIn')
           .callsFake(() => appContext.authService.authCheck());
+      stubRestApi('getPreferences').returns(Promise.resolve(
+          createPreferences()));
       element = basicFixture.instantiate();
       element._authService.clearCache();
       toastSpy = sinon.spy(element, '_createToastAlert');
diff --git a/polygerrit-ui/app/elements/diff/gr-selection-action-box/gr-selection-action-box.ts b/polygerrit-ui/app/elements/diff/gr-selection-action-box/gr-selection-action-box.ts
index ee52ab6..f38824f 100644
--- a/polygerrit-ui/app/elements/diff/gr-selection-action-box/gr-selection-action-box.ts
+++ b/polygerrit-ui/app/elements/diff/gr-selection-action-box/gr-selection-action-box.ts
@@ -23,6 +23,7 @@
 import {PolymerElement} from '@polymer/polymer/polymer-element';
 import {htmlTemplate} from './gr-selection-action-box_html';
 import {fireEvent} from '../../../utils/event-util';
+import {appContext} from '../../../services/app-context';
 
 declare global {
   interface HTMLElementTagNameMap {
@@ -56,6 +57,11 @@
   @property({type: Boolean})
   positionBelow = false;
 
+  @property({type: Boolean})
+  disableKeyboardShortcuts = false;
+
+  private restApiService = appContext.restApiService;
+
   /** @override */
   created() {
     super.created();
@@ -64,6 +70,18 @@
     this.addEventListener('mousedown', e => this._handleMouseDown(e));
   }
 
+  attached() {
+    this.restApiService.getPreferences().then(prefs => {
+      if (prefs?.disable_keyboard_shortcuts) {
+        this.disableKeyboardShortcuts = true;
+      }
+    });
+  }
+
+  _getTextForTooltip(disableKeyboardShortcuts: boolean) {
+    return disableKeyboardShortcuts ? 'Click to comment' : 'Press c to comment';
+  }
+
   placeAbove(el: Text | Element | Range) {
     flush();
     const rect = this._getTargetBoundingRect(el);
diff --git a/polygerrit-ui/app/elements/diff/gr-selection-action-box/gr-selection-action-box_html.ts b/polygerrit-ui/app/elements/diff/gr-selection-action-box/gr-selection-action-box_html.ts
index 24d63b3..d293967 100644
--- a/polygerrit-ui/app/elements/diff/gr-selection-action-box/gr-selection-action-box_html.ts
+++ b/polygerrit-ui/app/elements/diff/gr-selection-action-box/gr-selection-action-box_html.ts
@@ -27,7 +27,7 @@
   </style>
   <gr-tooltip
     id="tooltip"
-    text="Press c to comment"
+    text="[[_getTextForTooltip(disableKeyboardShortcuts)]]"
     position-below="[[positionBelow]]"
   ></gr-tooltip>
 `;
diff --git a/polygerrit-ui/app/elements/settings/gr-settings-view/gr-settings-view.ts b/polygerrit-ui/app/elements/settings/gr-settings-view/gr-settings-view.ts
index 809139d..3c00a47 100644
--- a/polygerrit-ui/app/elements/settings/gr-settings-view/gr-settings-view.ts
+++ b/polygerrit-ui/app/elements/settings/gr-settings-view/gr-settings-view.ts
@@ -76,6 +76,7 @@
   'email_strategy',
   'diff_view',
   'publish_comments_on_push',
+  'disable_keyboard_shortcuts',
   'work_in_progress_by_default',
   'default_base_for_merges',
   'signed_off_by',
@@ -114,6 +115,7 @@
     workInProgressByDefault: HTMLInputElement;
     showSizeBarsInFileList: HTMLInputElement;
     publishCommentsOnPush: HTMLInputElement;
+    disableKeyboardShortcuts: HTMLInputElement;
     relativeDateInChangeTable: HTMLInputElement;
   };
 }
@@ -384,6 +386,13 @@
     );
   }
 
+  _handleDisableKeyboardShortcutsChanged() {
+    this.set(
+      '_localPrefs.disable_keyboard_shortcuts',
+      this.$.disableKeyboardShortcuts.checked
+    );
+  }
+
   _handleWorkInProgressByDefault() {
     this.set(
       '_localPrefs.work_in_progress_by_default',
diff --git a/polygerrit-ui/app/elements/settings/gr-settings-view/gr-settings-view_html.ts b/polygerrit-ui/app/elements/settings/gr-settings-view/gr-settings-view_html.ts
index 11372a1..b141a86 100644
--- a/polygerrit-ui/app/elements/settings/gr-settings-view/gr-settings-view_html.ts
+++ b/polygerrit-ui/app/elements/settings/gr-settings-view/gr-settings-view_html.ts
@@ -278,6 +278,19 @@
           </span>
         </section>
         <section>
+          <label for="disableKeyboardShortcuts" class="title"
+            >Disable all keyboard shortcuts</label
+          >
+          <span class="value">
+            <input
+              id="disableKeyboardShortcuts"
+              type="checkbox"
+              checked$="[[_localPrefs.disable_keyboard_shortcuts]]"
+              on-change="_handleDisableKeyboardShortcutsChanged"
+            />
+          </span>
+        </section>
+        <section>
           <label for="insertSignedOff" class="title">
             Insert Signed-off-by Footer For Inline Edit Changes
           </label>
diff --git a/polygerrit-ui/app/mixins/keyboard-shortcut-mixin/keyboard-shortcut-mixin.ts b/polygerrit-ui/app/mixins/keyboard-shortcut-mixin/keyboard-shortcut-mixin.ts
index 881e102..9bd2f5a 100644
--- a/polygerrit-ui/app/mixins/keyboard-shortcut-mixin/keyboard-shortcut-mixin.ts
+++ b/polygerrit-ui/app/mixins/keyboard-shortcut-mixin/keyboard-shortcut-mixin.ts
@@ -107,6 +107,7 @@
   CustomKeyboardEvent,
   ShortcutTriggeredEventDetail,
 } from '../../types/events';
+import {appContext} from '../../services/app-context';
 
 /** Enum for all special shortcuts */
 export enum SPECIAL_SHORTCUT {
@@ -805,6 +806,10 @@
 
       ShortcutSection = ShortcutSection;
 
+      private _disableKeyboardShortcuts = false;
+
+      private restApiService = appContext.restApiService;
+
       modifierPressed(event: CustomKeyboardEvent) {
         /* We are checking for g/v as modifiers pressed. There are cases such as
          * pressing v and then /, where we want the handler for / to be triggered.
@@ -826,6 +831,7 @@
       }
 
       shouldSuppressKeyboardShortcut(event: CustomKeyboardEvent) {
+        if (this._disableKeyboardShortcuts) return true;
         const e = getKeyboardEvent(event);
         // TODO(TS): maybe override the EventApi, narrow it down to Element always
         const target = (dom(e) as EventApi).rootTarget as Element;
@@ -926,6 +932,13 @@
       /** @override */
       connectedCallback() {
         super.connectedCallback();
+
+        this.restApiService.getPreferences().then(prefs => {
+          if (prefs?.disable_keyboard_shortcuts) {
+            this._disableKeyboardShortcuts = true;
+          }
+        });
+
         const shortcuts = shortcutManager.attachHost(this);
         if (!shortcuts) {
           return;
diff --git a/polygerrit-ui/app/types/common.ts b/polygerrit-ui/app/types/common.ts
index 95801e7..cf7e37d 100644
--- a/polygerrit-ui/app/types/common.ts
+++ b/polygerrit-ui/app/types/common.ts
@@ -1763,6 +1763,7 @@
   email_strategy: EmailStrategy;
   default_base_for_merges: DefaultBase;
   publish_comments_on_push?: boolean;
+  disable_keyboard_shortcuts?: boolean;
   work_in_progress_by_default?: boolean;
   // The email_format doesn't mentioned in doc, but exists in Java class GeneralPreferencesInfo
   email_format?: EmailFormat;